SrasV1, Main, Exploration, bibRecord, 001982

Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells

Identifieur interne : 001982 ( Main/Exploration ); précédent : 001981; suivant : 001983

Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells

Auteurs : Xinrong Tao ; Terence E. Hill ; Chikao Morimoto ; Clarence J. Peters ; Thomas G. Ksiazek ; Chien-Te K. Tseng

Source :

Journal of Virology [ 0022-538X ] ; 2013.

RBID : PMC:3754134

Descripteurs français

KwdFr :
- Apoptose, Bronches (anatomopathologie), Bronches (virologie), Cellules épithéliales (anatomopathologie), Cellules épithéliales (virologie), Coronavirus (pathogénicité), Coronavirus (physiologie), Effet cytopathogène viral (physiologie), Humains, Libération de particules virales (physiologie), Lignée cellulaire, Polarité de la cellule, Pénétration virale, Spécificité d'espèce, Virus du SRAS (pathogénicité), Virus du SRAS (physiologie).
MESH :
- anatomopathologie : Bronches, Cellules épithéliales.
- pathogénicité : Coronavirus, Virus du SRAS.
- physiologie : Coronavirus, Effet cytopathogène viral, Libération de particules virales, Virus du SRAS.
- virologie : Bronches, Cellules épithéliales.
- Apoptose, Humains, Lignée cellulaire, Polarité de la cellule, Pénétration virale, Spécificité d'espèce.

English descriptors

KwdEn :
- Apoptosis, Bronchi (pathology), Bronchi (virology), Cell Line, Cell Polarity, Coronavirus (pathogenicity), Coronavirus (physiology), Cytopathogenic Effect, Viral (physiology), Epithelial Cells (pathology), Epithelial Cells (virology), Humans, SARS Virus (pathogenicity), SARS Virus (physiology), Species Specificity, Virus Internalization, Virus Release (physiology).
MESH :
- pathogenicity : Coronavirus, SARS Virus.
- pathology : Bronchi, Epithelial Cells.
- physiology : Coronavirus, Cytopathogenic Effect, Viral, SARS Virus, Virus Release.
- virology : Bronchi, Epithelial Cells.
- Apoptosis, Cell Line, Cell Polarity, Humans, Species Specificity, Virus Internalization.

Abstract

The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754134

DOI: 10.1128/JVI.01562-13
PubMed: 23824802
PubMed Central: 3754134

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells</title>
<author><name sortKey="Tao, Xinrong" sort="Tao, Xinrong" uniqKey="Tao X" first="Xinrong" last="Tao">Xinrong Tao</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hill, Terence E" sort="Hill, Terence E" uniqKey="Hill T" first="Terence E." last="Hill">Terence E. Hill</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morimoto, Chikao" sort="Morimoto, Chikao" uniqKey="Morimoto C" first="Chikao" last="Morimoto">Chikao Morimoto</name>
<affiliation><nlm:aff id="aff4"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peters, Clarence J" sort="Peters, Clarence J" uniqKey="Peters C" first="Clarence J." last="Peters">Clarence J. Peters</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G." last="Ksiazek">Thomas G. Ksiazek</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K." last="Tseng">Chien-Te K. Tseng</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23824802</idno>
<idno type="pmc">3754134</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754134</idno>
<idno type="RBID">PMC:3754134</idno>
<idno type="doi">10.1128/JVI.01562-13</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000815</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000815</idno>
<idno type="wicri:Area/Pmc/Curation">000815</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000815</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000A06</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A06</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:23824802</idno>
<idno type="wicri:Area/PubMed/Corpus">001171</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001171</idno>
<idno type="wicri:Area/PubMed/Curation">001171</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001171</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001219</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001219</idno>
<idno type="wicri:Area/Ncbi/Merge">002703</idno>
<idno type="wicri:Area/Ncbi/Curation">002703</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002703</idno>
<idno type="wicri:doubleKey">0022-538X:2013:Tao X:bilateral:entry:and</idno>
<idno type="wicri:Area/Main/Merge">001992</idno>
<idno type="wicri:Area/Main/Curation">001982</idno>
<idno type="wicri:Area/Main/Exploration">001982</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells</title>
<author><name sortKey="Tao, Xinrong" sort="Tao, Xinrong" uniqKey="Tao X" first="Xinrong" last="Tao">Xinrong Tao</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hill, Terence E" sort="Hill, Terence E" uniqKey="Hill T" first="Terence E." last="Hill">Terence E. Hill</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morimoto, Chikao" sort="Morimoto, Chikao" uniqKey="Morimoto C" first="Chikao" last="Morimoto">Chikao Morimoto</name>
<affiliation><nlm:aff id="aff4"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peters, Clarence J" sort="Peters, Clarence J" uniqKey="Peters C" first="Clarence J." last="Peters">Clarence J. Peters</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G." last="Ksiazek">Thomas G. Ksiazek</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K." last="Tseng">Chien-Te K. Tseng</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apoptosis</term>
<term>Bronchi (pathology)</term>
<term>Bronchi (virology)</term>
<term>Cell Line</term>
<term>Cell Polarity</term>
<term>Coronavirus (pathogenicity)</term>
<term>Coronavirus (physiology)</term>
<term>Cytopathogenic Effect, Viral (physiology)</term>
<term>Epithelial Cells (pathology)</term>
<term>Epithelial Cells (virology)</term>
<term>Humans</term>
<term>SARS Virus (pathogenicity)</term>
<term>SARS Virus (physiology)</term>
<term>Species Specificity</term>
<term>Virus Internalization</term>
<term>Virus Release (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Apoptose</term>
<term>Bronches (anatomopathologie)</term>
<term>Bronches (virologie)</term>
<term>Cellules épithéliales (anatomopathologie)</term>
<term>Cellules épithéliales (virologie)</term>
<term>Coronavirus (pathogénicité)</term>
<term>Coronavirus (physiologie)</term>
<term>Effet cytopathogène viral (physiologie)</term>
<term>Humains</term>
<term>Libération de particules virales (physiologie)</term>
<term>Lignée cellulaire</term>
<term>Polarité de la cellule</term>
<term>Pénétration virale</term>
<term>Spécificité d'espèce</term>
<term>Virus du SRAS (pathogénicité)</term>
<term>Virus du SRAS (physiologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Bronches</term>
<term>Cellules épithéliales</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Coronavirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bronchi</term>
<term>Epithelial Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term>
<term>Effet cytopathogène viral</term>
<term>Libération de particules virales</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term>
<term>Cytopathogenic Effect, Viral</term>
<term>SARS Virus</term>
<term>Virus Release</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Bronches</term>
<term>Cellules épithéliales</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Bronchi</term>
<term>Epithelial Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Apoptosis</term>
<term>Cell Line</term>
<term>Cell Polarity</term>
<term>Humans</term>
<term>Species Specificity</term>
<term>Virus Internalization</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Polarité de la cellule</term>
<term>Pénétration virale</term>
<term>Spécificité d'espèce</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Hill, Terence E" sort="Hill, Terence E" uniqKey="Hill T" first="Terence E." last="Hill">Terence E. Hill</name>
<name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G." last="Ksiazek">Thomas G. Ksiazek</name>
<name sortKey="Morimoto, Chikao" sort="Morimoto, Chikao" uniqKey="Morimoto C" first="Chikao" last="Morimoto">Chikao Morimoto</name>
<name sortKey="Peters, Clarence J" sort="Peters, Clarence J" uniqKey="Peters C" first="Clarence J." last="Peters">Clarence J. Peters</name>
<name sortKey="Tao, Xinrong" sort="Tao, Xinrong" uniqKey="Tao X" first="Xinrong" last="Tao">Xinrong Tao</name>
<name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K." last="Tseng">Chien-Te K. Tseng</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001982 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001982 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3754134
   |texte=   Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:23824802" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

Serveur d'exploration SRAS

Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells

Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.